Semen-coicis extract with function of reducing blood uric acid and method for preparing same

[0018] Capsule preparation

[0019] Add 6 times the amount of ethyl acetate to coix seed and ultrasonically extract twice, 1.5 hours each time, concentrate the extract, mix the extract and microcrystalline cellulose at a mass ratio of 1:2, dry, crush, and add 1% sucrose ester , 0.5% magnesium stearate, and filled into hard capsules.

[0021] tablet preparation

[0022] Coix seed is added with 10 times the amount of 80% ethanol and heated under reflux to extract twice, 1 hour each time, the extract is concentrated, the coix seed extract and microcrystalline cellulose are mixed according to the mass of 1:2, dried, crushed, added to disintegrate Agent and other auxiliary materials such as micro-powder silica gel are mixed evenly, granulated and pressed into tablets.

[0024] Study on the effect of coix seed extract on lowering blood uric acid

[0025] 1. Experimental animals and materials

[0026] 1.1 Animals

[0027] Sixty adult male quails were purchased from a vegetable market in Hangzhou. The animals were kept in a clean animal breeding room and had free access to food and water. Light and dark alternated for 12 hours. The room temperature is 24-26°C and the relative humidity is 70%.

[0028] 1.2 Materials and Instruments

[0029] Uric acid (LOT: STB7849V, Sigma-Aldrich Co.Ltd.); olive oil; coix seed; allopurinol (lot number: 090102, Chongqing Qingyang Pharmaceutical Co., Ltd.); Tween-80 (lot number: 20090901, Wenzhou Qingming Chemical Co., Ltd.); ethanol, sucrose ester, microcrystalline cellulose (Huadong Pharmaceutical Co., Ltd. Chemical Agent Branch); sodium carboxymethylcellulose (batch number: 010923, Shanghai Celluloid Factory) rotary evaporator; water bath; round bottom flask ; Alcohol meter.

[0030] 1.2 Experimental meth...